Halogen bonding in halocarbon-protein complexes
نویسندگان
چکیده
Halogen bonding (XB) has been extensively described in the context of a variety of self-assembled supramolecular materials with specific structural properties. However, it has so far received only little recognition for its possible role in the stabilization of the interactions between small chemicals and large biomolecules. Here, we provide three examples of halogen bonding occurring between small halogen-substituted ligands and their biological substrates. The crystal structures presented here, where iodine and bromine atoms function as halogen bonding donors and different electron rich sites, such as oxygen and nitrogen, function as halogen bonding acceptors, prove how halogen bonding can occur in biological systems and provide a class of higly directional stabilizing contacts that can be exploited in the process of rational drug design.
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